Re: Weight Loss Clinical Trial - 29 Week Long Study

Dear Volunteers:

We face a major health problem in the United States - obesity. This new research study is looking for volunteers who are serious about staying in the program. Both men and women are welcome to apply, so please tell your spouse or significant other if you think they would be interested in participating in this with you.

I am conducting a clinical research study to evaluate the safety and effectiveness of an investigational drug for weight loss in overweight or obese persons. To be considered for participation in this research study, you must be 18 to 65 years old and meet all the entry criteria including Body Mass Index or BMI measurements. BMI is a calculation, which combines your gender, height, weight, and waistline measurements. The higher a person's BMI score the higher the health risk. Study staff at my site will review all additional criteria with you to determine if you're eligible.

If you are eligible and decide to participate, you must be willing to attend up to 14 office visits over approximately 29 weeks. Participation in this research study includes, at no cost:

• Physical exams
• Close monitoring and study-related care - including Lifestyle Intervention programs, lab tests, and electrocardiograms (ECGs), which is a test that measures the electrical activity of the heart.
• Investigational Study Medication
• DEXA scan(s) for body composition - a test that uses low dose x-rays to measure body fat and fat distribution.
• Compensation for time and travel expenses

If you are interested, know someone who may be interested in this study, or have general questions about clinical research, please contact the Coastal Carolina Research Center at 843/856-3784, email us at ccrc@coastalcarolinaresearch.com or check out our new website www.coastalcarolinaresearch.com and sign up online under Volunteer Section in the link called "Current Studies".

To respect your interest and commitment in volunteering for a clinical research study, we offer flexible appointment scheduling and are happy to answer any of your questions or concerns.

We look forward to hearing from you.

Sincerely,

Cynthia B. Strout, MD
Medical Director, Coastal Carolina Research Center

Summary: Serious Volunteers only for Weight Loss Clinical Research Study!!!

To qualify you must:

• Between 18 to 65 years of age
• Have a Body Mass Index (BMI) that meet the study requirements

Duration: Up to 14 visits over approximately 29 weeks

Qualified participants will receive all the following at no cost:

• Study related:
  • Physical Exams
  • Investigational study medication
  • Behavior Modification program
  • Lab work
  • Electrocardiograms (ECGs) - test that measures the electrical activity of the heart
  • DEXA scan(s) for body composition - a test that uses low dose x-rays to measure body fat and fat distribution

Compensation will be provided for time and travel expenses

Our contact information is noted below if you are interested or you can check out our new website at www.coastalcarolinaresearch.com and sign up for this study online under the Volunteer section noted as "Current Studies".

Please note that all persons who respond to the study via the internet will be contacted by telephone and may be entered into our patient database. All information provided by the subject during the course of this study will be treated with a high level of confidentiality and will adhere to any applicable federal, state or local regulations.

Contact:
Coastal Carolina Research Center
1156 Bowman Rd. Ste. 102
Mount Pleasant, SC 29464
Telephone: 843-856-3784
Fax: 843-856-3788
Email: ccrc@coastalcarolinaresearch.com